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• LCModel軟件相關(guān)論文分享——磁共振頻譜數(shù)據(jù)定量后處理技術(shù)比較
• LCModel 軟件是一款頻譜定量軟件。操作完全自動化，能直接輸出代謝物出的絕對濃度，兼容 Siemens, GE, Philips 等各大廠商和不同掃描序列（PRESS, STEAM等）的波譜數(shù)據(jù)。該軟件經(jīng)過18年的開發(fā)和全世界超過500家大型科研院所的試用，已逐漸成為事實(shí)上的波譜數(shù)據(jù)規(guī)范后處理平臺。HMRRC于2010年引進(jìn)了LCModel并將利用該軟件對多種疾病，尤其是神經(jīng)精神疾病展開研究。
  
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• 當(dāng)前LCModel的新版本為6.3，在該版本中，主要升級的內(nèi)容有：
• 1、用MEGA-PRESS估算GABA 。
• 2、改進(jìn)了較弱代謝物的估計，特別是谷氨酰胺。
• 3、改進(jìn)肌肉，脂質(zhì)，乳腺和肝臟光譜分析。
• 磁振造影 (MRI) 與磁振頻譜 (MRS) 具有非侵入性探測的特色，所以被廣泛地發(fā)展以應(yīng)用在臨床分析的研究上。
• 近年來隨著MRS應(yīng)用于臨床的例子增加，所以也發(fā)展出許多針對后處理的工具軟件，其中廣為人知的后處理軟件為LCModel。LCModel 是套被廣泛使用的磁振頻譜分析軟體。采用了圖形操作介面讓使用者對于磁振頻譜影像的分析達(dá)到方便以及簡潔的目的。LCMgui 是其在Linux系統(tǒng)中的圖形使用者介面，可以轉(zhuǎn)換多種磁振頻譜檔案格式到LCModel可處理的檔案格式。
• 特征
• 算法的小改進(jìn)意味著結(jié)果會略有不同。
• 對光譜的分析主要是脂質(zhì)(以及水，可能是膽堿)，如脊椎、乳房和肝臟
• 肌譜分析
• 導(dǎo)入到電子表格程序的輸出文件
• 通用多通道(相控陣)檔案。
• 同時分析水信號的左邊和右邊
• 對脂質(zhì)和大分子信號的估計，特別是對腫瘤和病變的評估
• 交互式選擇和分析MRSI切片的矩形子集
• Bruker、西門子公司和東芝的數(shù)據(jù)與LCMgui
• 多用戶安裝LCMgui
• 使用LCMgui中的擴(kuò)展來歸檔文件
• LCMgui用戶配置文件
• 使用LCMgui進(jìn)行多個分析的批處理
• 選擇通用電氣LX(和更高)框架的子集
• 文件名過濾器在LCMgui文件選擇器中
• 更方便地處理非共振譜
• 模擬基礎(chǔ)光譜
• 對濃度比率施加“軟約束”
• 相干平均譜(如:從相控陣)
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• Features
• Small improvements in the algorithms mean that the results will differ slightly.
• Analysis of spectra with mainly lipid (and water plus possibly choline), as in vertebra,breast and liver.
• Small improvements in the algorithms mean that the results will differ slightly.
• Analysis of muscle spectra, particularly for IMCL.
• Bruker ParaVision-3 files.
• Output file for import to spreadsheet programs.
• In multi-voxel analyses: combining PostScript files into one file; skipping over bad voxels.
• GE multi-channel (phased-array) P-files.
• Simultaneously analyzing a spectrum left & right of the water signal.
• Estimation of lipid and macromolecule signals, especially for tumors and lesions.
• Interactive selection and analysis of rectangular subsets of MRSI slices.
• Bruker, Siemens syngo and Toshiba data with LCMgui.
• Multi-User installations of LCMgui.
• Archiving files using extensions in LCMgui.
• LCMgui user profiles, e.g., for 1.5T & 3T data or Siemens & GE data on the same user account.
• Batch processing of multiple analyses with LCMgui).
• Selecting a subset of GE LX (and higher) frames, e.g., to eliminate bad frames due to patient motion.
• Filename filters in the LCMgui File Selector.
• More convenient handling of off-resonance spectra.
• Simulating your own basis spectra.
• Imposing "soft constraints" on concentration ratios.
• Coherent averaging of spectra (e.g., from phased arrays).
• Going back toward the old Version 5, e.g., for improved (but not perfect) consistency in large longitudinal studies.
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• The normal usage is to supply the time-domain data as a simple text file to LCModel. A possible alternative is the LCMgui graphical user interface:
• Freely available for use with LCModel.
• Simplified usage, often only with mouse clicks, in two steps:
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• 1.Select the data with the File Selector;
• 2.Start LCModel (optionally checking and modifying any settings) in the Control Window.
• Currently for the following single-voxel data:
• Bruker ParaVision fid files (if necessary, converted by you to analog mode with Bruker's convdta).
• GE 5.x Probe raw P-files and spectrum G-files.
• GE Probe raw P-files, including (new) Signa 22 P-files. Also for P-files with multi-channel (phased-array) data.
• Hitachi data: part of the Hitachi software; no need to purchase separately.
• Philips SDAT & SPAR files.
• Picker (later Marconi, now Philips) DUMP files.
• Siemens rda files transferred from the syngo PC console and Siemens raw files from the (old) Numaris-3 Unix console.
• Toshiba rawData files and Version 7.xx (and later) DICOM files;
• Varian/Agilent fid files;
• Other data types using your own conversion script.
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• Currently for the following MRSI data:
• Philips, Siemens & Toshiba data, including interactive display, selection and analysis of full 2D slices or rectangular subsets. (Instructions in Sec. 3.7 of the LCModel Manual.)
• Other data types using your own conversion script;
• For GE MRSI (and single-voxel) data, Mary McLean's LCModel interface [MA McLean et al, Magn Reson Med 44, 401 (2000)] is integrated into GE's SAGE Research version (from SAGE Dev2002.1).
• 軟件操作系統(tǒng)要求:
• A Linux PC with an AMD or Intel processor(s) (including x86-64). No Microsoft or Apple versions are planned.
• You must be able to print or display PostScript files (or convert PostScript, e.g., to PDF with Adobe Acrobat Distiller).
• An X-windows display. (This is checked for you in Step 2 of the test run below.)
• A monitor with reasonable resolution (at least 1024 x 768).
• You log on under your normal username (not root);
• And you can at any time completely remove your installed package (including all output from the tests) with the command: $HOME/.uninstall-lcmodel
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• 計算機(jī)硬件要求：
• An LCModel analysis makes full use of one processor's speed and CPU cache memory. It makes no use of multiple processors (unless several analyses run simultaneously).
• There is very little input/output or demands on graphics, memory or disk storage.
• 512 MB of memory should be sufficient, at least for a single user.
• LCModel should run with almost any Linux distribution from 2001 or later. Most popular are Ubuntu, Red Hat & CentOS.
• You should check all of this on your own computer with the free download and test runs.